Abstract NOTCH1 signaling, a vital regulator of cell proliferation and differentiation, is widely involved in the occurrence and development of malignant tumors.Pharmacological regulation of NOTCH1 is promising in Womens Jackets tumor immunotherapy, whereas the effective rate of existing therapies remains low.NOTCH1 functions, as a cancer suppresso
Abstract Background Protothecosis is a rare infection in humans and animals caused by the achlorophyllic algae Prototheca species.More than half of the protothecosis cases are cutaneous Skirt infections, and most cases are observed in immunocompromised individuals.Case presentation We report a case of Prototheca wickerhamii infection in the mucosa
BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the lung phenotype including excessive extracellular matrix deposition, myofibroblast foci, alveolar epithelial cell hyperplasia and extensive remodeling.The role of epigenetic changes in determining the lung phenotype in IPF is unknown.In this study we determine
Abstract Background An increasing number of studies have profiled tumor specimens using distinct microarray platforms and analysis techniques.With the accumulating amount of microarray data, one of the most intriguing yet challenging tasks is to develop robust statistical models Tumbler to integrate the findings.Results By applying a two-stage Baye